Glyphosate causes leukemia early in life

A global study confirms, even at doses considered "safe" by regulators, that glyphosate causes leukemia and premature death. As part of the possible extension of the approval of this herbicide by the EU, this is another example of the consequences of an agricultural model based on agrochemicals.

An international, multi-institutional, long-term toxicity study, recently presented in Bologna, Italy, found that “Low doses of this herbicide cause leukemia in mice. It should be noted that half of the leukemia deaths observed in the study groups occurred at an early age", states the official statement that accompanies the presentation.

The data presented on Wednesday, October 25, were published during the international scientific conference “Environment, work and health in the 21st century: strategies and solutions to a global crisis” and are part of the Global Glyphosate Study (GGS).

In the current study, the scientists used only that herbicide and two commercial brands, Roundup BioFlow (MON 52276), used in the EU, and Ranger Pro (EPA 524-517), used in the US, administered to rats at through drinking water from the prenatal stage at a rate of 0,5, 5 and 50 mg/kg body weight/day.

Study results confirming that glyphosate causes leukemia

Daniele Mandrioli, global research coordinator and director of the Ramazzini Institute, highlighted that "approximately half of the leukemia deaths were seen in mice exposed to the herbicide and occurred before one year of age".

The results raise questions about the justification for the use of herbicides. The doses used in this study are currently considered by regulatory authorities to be safe and in line with the EU Acceptable Daily Intake (ADI) and No Observed Side Effects (Noael) levels for this herbicide.

Mandrioli announced that the full study will be published soon and explained the reasons for this step. “These results are so important for public health that we decided to present them now before publication. The complete data will be made available to the public in the coming weeks and published in scientific journals".

The Complete Study Ever Conducted on the Health Consequences of Herbicide

The Global Glyphosate Study is the most comprehensive toxicity study ever conducted on these herbicides. Its effects on carcinogenicity, neurotoxicity, multigenerational effects, organ toxicity, endocrine disruption and prenatal developmental toxicity.

GGS previously published a pilot study showing hormonal and reproductive toxicity in rats at the dose currently considered safe by US regulators (1,75 mg/kg body weight/day). These results were later confirmed in a cohort of mothers and babies exposed during gestation.

The GGS results on the microbiome toxicity of glyphosate, peer-reviewed and published in late 2022 and presented to the European Union Parliament in 2023, also showed adverse effects at doses currently considered safe and permitted in the EU (0,5 .XNUMX mg/kg bw/day, equivalent to the acceptable daily intake in the EU) The coordinator of the GGS project is the Italian Ramazzini Institute, in which scientists from Europe, the United States and South America participate.

The following American universities participated in the study: Boston, Icahn Medicine at Mount Sinai, George Mason and California. The University of Padua (Italy), King's College (United Kingdom), Copenhagen (Denmark) and the Federal University of Paraná (Brazil) also participated.

“The renewal of the Glyphosate license is completely illegal”

In 2015, the WHO's International Agency for Research on Cancer (IARC) classified it as a probable human carcinogen.

Despite this announcement, most regulatory bodies, including Argentina's National Agricultural Health and Quality Service (Senasa), continue to allow the use of this dangerous herbicide.

The improvement in GGS results is due to the fact that the European Union extended the approval of the herbicide and a decision is expected in these months.

A solution that attracts the attention of all EU Member States, as well as the entire international community, in an effort to eliminate dangerous herbicides used by the world's largest agrochemical companies on the market.

Immediately after the study data became known, German toxicologist Peter Clausing, a member of the Pesticide Action Network (PAN), stated in a statement from the organization: “This high-quality study needs the full attention of the European authorities. "as it provides alarming new evidence that corroborates previous findings on the carcinogenic effects of this herbicide on the lymphatic system observed in studies with mice and in epidemiological studies in humans."

For her part, Angélica Lisimashu, director of Science and Policy (PAN Europe), concluded: "The study highlights that renewing the glyphosate license is more than questionable, it is completely illegal. The European Union authorities have made a huge mistake in concluding that this herbicide and its representative formulation are safe. The right step now is for the EU to withdraw the current reauthorization proposal and press for it not to be renewed"

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